WebThis technique is based on quantifying protein-specific aptamer binding using a DNA micro-array. Version 3 of the SOMAscan assay convers 1129 distinct proteins. A total of 352 previously unthawed aliquots of 200 μL of EDTA plasma from QMDiab participants was analysed at the WCM-Q proteomics core facility using this assay. WebApr 13, 2024 · The fast, accurate detection of biomolecules, ranging from nucleic acids and small molecules to proteins and cellular secretions, plays an essential role in various biomedical applications. These include disease diagnostics and prognostics, environmental monitoring, public health, and food safety. Aptamer recognition (DNA or RNA) has gained …
SomaScan Assay - Products and Services - SomaLogic
WebMar 9, 2024 · We performed multiplexed analysis of BNP and NT-proBNP as several large cohort studies have identified these two biomarkers as direct indicators of heart failure. 5, 6 First, we tested the MP with an NT-proBNP binding aptamer and validated its performance for monitoring NT-proBNP in the clinically relevant range, 100 pg mL −1 to 1800 pg mL −1 … bipolar i disorder with rapid cycling
Proteomics Analysis of Cancer Exosomes Using a Novel Modified …
WebJan 27, 2024 · This assay is a highly multiplexed and high-throughput affinity proteomics platform based on the ability of modified aptamers (modified small single-stranded oligonucleotides) to bind >1300 target proteins with high specificity and affinity at slow dissociation rates. 22-29 We supplemented this data set with proteomic analysis of PB … WebApr 11, 2024 · Although the method was reported to be limited by the data visualization after electrophoresis, it could achieve a simultaneous detection of up to six foodborne bacteria, which is more than reported for previously published multiplex PCR assays based on selective primers (Chen et al., 2012; Yuan et al., 2009). WebApr 11, 2024 · Background We sought to discover serum biomarkers of ankylosing spondylitis (AS) for diagnosis and monitoring disease activity. Methods We studied … dallas area school district pa jobs