Topcat trial post hoc analysis

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August undefined, 2024

Web期刊：Intensive Care Medicine文献作者：Gael Piton; Amélie Le Gouge; Julie Boisramé-Helms; Nadia Anguel; Laurent Argaud; Pierre Asfar; Vlad Botoc; Anne Bre ... Factors associated with acute mesenteric ischemia among critically ill ventilated patients with shock: a post hoc analysis of the NUTRIREA2 trial Web2. nov 2024 · This is a post hoc analysis of the TOPCAT trial. We obtained the data from the Biologic Specimen and Data Repository Information Coordinating Center of the US National Heart, Lung, and Blood Institute via an approved proposal. TOPCAT was a multicenter, international, randomized, double-blinded placebo-controlled trial, which enrolled 3,445 ...

Pre-specified vs. post-hoc subgroup analyses: are we wiser before …

Web1. apr 2024 · Post hoc analysis of the TOPCAT reported differential response to spironolactone therapy in patient with HFpEF when grouping by clinical phenotypes . However, it remains unknown whether the potential benefits vary in patients at different baseline risks. ... We also performed a separate analysis in Americas cohort of TOPCAT … WebAbstract. Background: Mineralocorticoid receptor antagonists (MRAs) reduce the risk of atrial fibrillation (AF) in patients with heart failure (HF) and a reduced ejection fraction. … bounty twins

Regional Variation in Patients and Outcomes in the Treatment of

Web10. jan 2024 · trial leadership by clearly indicating that the slide was “an additional post hoc exploratory analysis by region. ” This outside-the-SAP analysis showed for the ﬁrst time a reduc-tion in event rates with spironolactone in the Americas (haz-ard ratio, 0.82; 95% CI, 0.69 to 0.98). Our position at that time was carefully phrased, “…we Web1. mar 2024 · A total of 1767 HFpEF patients from Americas in the TOPCAT trial were included in our analysis. Ischemic event was defined as myocardial infarction or ischemic … Web6. jan 2015 · This post hoc analysis demonstrated greater potassium and creatinine changes and possible clinical benefits with spironolactone in patients with heart failure … bounty tyčinka

Distinct implications of body mass index in different subgroups of ...

The Primary Outcome Fails — What Next? NEJM

Web18. feb 2024 · Based on the data of the TOPCAT trial, this was the first study designed to assess the predictive performances of the C 2 HEST score for predicting incident AF as well as other trial adjudicated outcomes including stroke, death, and hospitalization in symptomatic HFpEF patients. guided ice fishing trips in wisconsinWebZurück zum Zitat Ahmed A, Rich MW, Love TE et al. Digoxin and reduction in mortality and hospitalization in heart failure: a comprehensive post hoc analysis of the DIG trial. Eur Heart J. 2006;27:178–86 CrossRefPubMed Ahmed A, Rich MW, Love TE et al. Digoxin and reduction in mortality and hospitalization in heart failure: a comprehensive ... bounty\u0027s

"Web10. apr 2014 · Post hoc analysis indicated marked regional differences in event rates (Table S6 in the Supplementary Appendix ). In the Americas (the United States, Canada, Brazil, and Argentina), the... " - Topcat trial post hoc analysis

Topcat trial post hoc analysis

Outpatient diuretic intensification as endpoint in HFpEF trials: an ...

Web1. apr 2016 · All cardiovascular approvals (12 drugs, 29 trials) and neurologic approvals (26 drugs, 54 trials) were analyzed, as well as a random sample of cancer approvals (28 of 85 drugs [33%]) matched to ... WebTOPCAT is an interactive graphical viewer and editor for tabular data. Although a general purpose tool capable of handling large and sparse datasets with correlation functionality …

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Web10. apr 2014 · The new england journal of medicine 1384 n engl j med 370;15 nejm.org10, 2014 april M any patients with heart failure have a normal or near-normal left ven - tricular … Web15. okt 2004 · Neefs J, van den Berg NWE, Krul SPJ, Boekholdt SM, de Groot JR. Effect of Spironolactone on Atrial Fibrillation in Patients with Heart Failure with Preserved Ejection Fraction: Post-Hoc Analysis of the Randomized, Placebo-Controlled TOPCAT Trial. Am J Cardiovasc Drugs. 2024 Feb;20(1):73-80. doi: 10.1007/s40256-019-00353-5.

WebPred 1 dňom · A meta-analysis of 31 trials including 48 429 patients with CKD demonstrated statin-dependent LDL-C lowering to significantly reduce cardiovascular risk by 23% and all-cause mortality by 9% in the CKD population. 16 In the SHARP Trial (Study of Heart and Renal Protection), 9270 patients with CKD (mean eGFR, 26.6 mL/min; including 20% with a … WebPost hoc analyses: after the facts Prospective clinical trials are constructed with high levels of internal validity. Sample size and power considerations usually address primary endpoints. Primary endpoints have traditionally included events that are becoming increasingly less common and thus have led to growing use of composite end …

Web1. sep 2016 · This post hoc subgroup analysis served as the motivation for the ongoing EXCEL trial 24 of PCI versus CABG in patients with left main coronary artery disease and … Web28. júl 2024 · Next, we submitted a request for accessing the TOPCAT Trial data along with a protocol for the intended post hoc analysis and the approval by the ethics committee of the First Affiliated Hospital, Sun Yat‐Sen University, Guangzhou, China. After we signed a Research Materials Distribution Agreement, National Heart, Lung, and Blood Institute ...

Web4. okt 2024 · For this post-hoc analysis, clinical data from TOPCAT were collected from the National Heart, Lung, and Blood Institute's Biological Specimen and Data Repository …

Web18. nov 2013 · TOPCAT randomized 3445 heart-failure patients at least age 50 with an LVEF > 45% at 270 sites in six countries to receive the aldosterone antagonist or placebo. … guided iguana hunting floridaWeb18. sep 2024 · A recent analysis of TOPCAT participants demonstrated that abdominal obesity was associated with increased risk of all-cause mortality. 23 Additionally, the existence of a unique HFpEF phenotype in obese patients has been postulated. 24 We believe this finding deserves further investigation. guided imagery activitiesWeb24. máj 2024 · In the randomized, placebo-controlled TOPCAT study of spironolactone in patients with heart failure (HF) and preserved left ventricular ejection fraction, spironolactone showed no benefit for the primary outcome of cardiovascular death, HF hospitalization, and cardiac arrest ( NEJM JW Cardiol May 2014 and N Engl J Med 2014; … guided hikes in sedona azWeb1. apr 2016 · The event rate in Russia was 35% lower than the average of other countries (p = 0.017), 56% lower than the United States (p < 0.0001), and 2.6-fold higher than Georgia (p = 0.010). The statistical analysis of the event rates in Table 1 is post hoc and was not performed at the time of data review. However, the lower event rate in Georgia was ... guided imagery beach youtubeWeb19. jún 2024 · A post-hoc analysis of the TOPCAT (Treatment of Cardiac Function with an Aldosterone Antagonist; NCT00094302) trial assessed the influence of AF at baseline on … bounty\u0027s captainWeb24. máj 2024 · With a study population drawn from the Western Hemisphere, Russia, and Georgia, post hoc analysis identified geographic differences in patient profiles, event … guided imagery activities for kidsWeb18. mar 2014 · The clinical benefit of albumin that was seen in the post hoc analysis of the subgroup of patients with septic shock warrants further confirmation. ... Editorial Lessons from the TOPCAT Trial J.J ... bounty\u0027s apartments ruaka